Does it take a lot of work to set this up?

No! You select these four things (unit, shift, interventions, reminders) from menus which require just a few taps on your iPhone or iPod Touch -- preferably while you're taking report from the outgoing nurse -- and then you're ready to start working your shift. Things are constantly changing and with a few taps you can add interventions and reminders on the fly, at any time during your shift.